教育与工作经历
2009.09-2013.06 湖北大学化学化工学院，学士
2013.09-2018.06 武汉大学化学与分子科学学院，博士，导师：周翔 教授
2018.07-2022.05 武汉大学化学与分析科学学院，博士后，导师：周翔 教授 宋保亮 教授
2022.06-至今 武汉大学公共卫生学院，特聘副研究员
研究方向
长期从事核酸化学生物学研究。基于化学探针对核酸的识别，开发核酸表观遗传修饰检测技术，寻找核酸修饰与重大疾病的关系，探讨疾病的致病机制
承担项目与课题
1.国家自然科学基金委青年基金项目“基于化学标记的单碱基分辨率绘制转录组中5-醛基胞嘧啶谱图的研究”，21907077，2020/1-2022/12，主持
2. 2018年度“博士后创新人才支持计划”（人力资源社会保障部和全国博士后管委会），BX201800225，2018/6-2020/6，主持
3. 第65批中国博士后科学基金面上项目“DNA中修饰碱基-尿嘧啶的单碱基分辨率检测技术的研究”，2019M652691，2019/5-2020/6，主持
4. 2018湖北省博士后科技活动项目择优资助，5-醛基嘧啶检测的新技术新方法的开发及其在疾病诊断中的应用，2018/11-2020/6，主持
获奖与荣誉
1. 中国化学会第32届学术年会优秀墙报奖
2. 中国化学会第31届学术年会优秀墙报奖
3. 2018 中国“博士后创新人才支持计划”
代表性论文
1.Yafen Wang* and Xiang Zhou, N6-methyladenosine and Its Implications in Viruses, Genomics, Proteomics & Bioinformatics, 2022, in press.
2.Yafen Wang, Wei Yang and Xiang Zhou*, Chemical labelling for m6A detection: opportunities and challenges, Fundamental Research, 2022, 2 (1), 56−58.
3.Yafen Wang#, Zonggui Chen#, Xiong Zhang#, Xiaocheng Weng#, Jikai Deng#,Wei Yang, Fan Wu, Shaoqing Han, Chao Xia, Yu Zhou, Yu Chen and Xiang Zhou*, Single-Base Resolution Mapping Reveals Distinct 5-Formylcytidine in Saccharomyces cerevisiae mRNAs, ACS Chemical Biology, 2022, 17 (1), 77−84. (Front Cover)
4.Yafen Wang#, Shaoqing Han#, Ruoxi Ran#, Anling Li#, Huanyu Liu, Mingjun Liu, Yongwei Duan, Xiong Zhang, Xiaocheng Weng*, Songmei Liu* and Xiang Zhou*, A longitudinal sampling study of transcriptomic and epigenetic profiles in patients with thrombocytopenia syndrome, Nature Communications, 2021, 12:5629. (Editor’s Highlights)
5.Yafen Wang#, Xiong Zhang#, Shaoqing Han#, Wei Yang, Zonggui Chen, Fan Wu, Jizhou Liu, Xiaocheng Weng* and Xiang Zhou*, Base-Resolution Analysis of Deoxyuridine at Genome Scale Based on Artificial Incorporation Modified Nucleobase, ACS Central Science, 2021, 7 (6), 973−979. (Front Cover)
6.Yafen Wang, Xiong Zhang, Hui Liu and Xiang Zhou*, Chemical Methods and Advanced Sequencing Technologies for Deciphering mRNA Modifications, Chemical Society Reviews, 2021, 50 (24), 13481–13497.
7.Jizhou Liu#, Wei Yang#, Xiong Zhang, Yafen Wang#* and Xiang Zhou*, Bisulfite-free and quantitative detection of 5-formylcytosine in DNA through qPCR, Chemical Communications, 2021, 57 (100), 13796–13798.
8.Wei Yang#, Shaoqing Han#, Xiong Zhang#, Yafen Wang#, Guangrong Zou, Chaoxing Liu, Muxin Xu, and Xiang Zhou*, Sequencing 5-formyluracil in genomic DNA at single-base resolution, Analytical Chemistry, 2021, 93 (46), 15445−15451.
9.Hongmei Yang#, Yafen Wang#, Jing Tang, Fang Wang* and Zilin Chen*, End-labeling-based electrochemical strategy for detection of adenine methylation in nucleic acid by differential pulse voltammetry, Microchimica Acta, 2021, 188 (8):250.
10.Yafen Wang, Xiong Zhang, Guangrong Zou, Shuang Peng, Chaoxing Liu and Xiang Zhou*, Detection and Application of 5-Formylcytosine and 5-Formyluracil in DNA, Accounts of Chemical Research, 2019, 52 (4), 1016−1024. (Supplementary Cover)
11.Yafen Wang#, Xiong Zhang#, Fan Wu, Zonggui Chen and Xiang Zhou*, Bisulfite-free, single base-resolution analysis of 5-hydroxymethylcytosine in genomic DNA by chemical-mediated mismatch, Chemical Science, 2019, 10 (2), 447−452.
12.Xiong Zhang #, Yafen Wang # and Xiang Zhou*, A Ligation-Based qPCR Amplification Assay for the Radiolabeling-Free Detection of ATP/NAD+ with High Selectivity and Sensitivity, Analytical Chemistry, 2019, 91 (2),1665−1670.
13.Yafen Wang #, Chaoxing Liu #, Fan Wu #, Xiong Zhang, Sheng Liu, Zonggui Chen, Weiwu Zeng, Wei Yang, Xiaolian Zhang, Yu Zhou, Xiaocheng Weng, Zhiguo Wu and Xiang Zhou*, Highly Selective 5-Formyluracil Labeling and Genome-wide Mapping Using (2-Benzimidazolyl)Acetonitrile Probe, iScience, 2018, 9, 423−432.
14.Yafen Wang#, Chaoxing Liu#, Xiong Zhang#, Wei Yang, Fan Wu, Guangrong Zou, Xiaocheng Weng* and Xiang Zhou*, Gene specific-loci quantitative and single-base resolution analysis of 5-formylcytosine by compound-mediated polymerase chain reaction, Chemical Science, 2018, 9 (15), 3723−3728.
15.Yafen Wang #, Chaoxing Liu #, Wei Yang #, Guangrong Zou, Xiong Zhang, Fan Wu, Shuyi Yu, Xiaomeng Luo and Xiang Zhou*, Naphthalimide derivatives as multifunctional molecules for detecting 5-formylpyrimidine by both PAGE analysis and dot-blot assays, Chemical Communications, 2018, 54 (12), 1497−1500.
16.Chaoxing Liu #, Yafen Wang #, Wei Yang, Fan Wu, Weiwu Zeng, Zonggui Chen, Jinguo Huang, Guangrong Zou, Xiong Zhang, Shaoru Wang, Xiaocheng Weng, Zhiguo Wu, Yu Zhou and Xiang Zhou*, Fluorogenic labeling and single-base resolution analysis of 5-formylcytosine in DNA, Chemical Science, 2017, 8 (11), 7443−7447.
17.Chaoxing Liu #, Yafen Wang #, Xiong Zhang, Fan Wu, Wei Yang, Guangrong Zou, Qian Yao, Jiaqi Wang, Yuqi Chen, Shaoru Wang and Xiang Zhou*, Enrichment and fluorogenic labelling of 5-formyluracil in DNA, Chemical Science, 2017, 8 (6), 4505−4510.
18.Chaoxing Liu #, Yuqi Chen #, Yafen Wang #, Fan Wu, Xiong Zhang, Wei Yang, Jiaqi Wang, Yi Chen, Zhiyong He, Guangrong Zou, Shaoru Wang, and Xiang Zhou*, A highly efficient fluorescence-based switch-on detection method of 5-formyluracil in DNA, Nano Research, 2017, 10 (7), 2449−2458.
19.Yafen Wang, Chaoxing Liu, Tianlu Wang, Tingting Hong, Haomiao Su, Shuyi Yu, Hongwei Song, Songmei Liu, Xin Zhou, Wuxiang Mao* and Xiang Zhou*, Highly Selective Detection of 5-Methylcytosine in Genomic DNA Based on Asymmetric PCR and Specific DNA Damaging Reagents, Analytical Chemistry, 2016, 88 (6), 3348−3353.
