教育与工作经历
2000.09-2004.06 武汉大学化学系，学士，导师万婕教授
2004.09-2009.11 武汉大学化学系，博士，导师周翔院士
2010.05-2012.05 武汉大学生命科学学院，博士后，导师吴建国教授
2012.11-2015.10 武汉大学化学与分子科学学院，副教授
2015.11-至今 武汉大学化学与分子科学学院， 教授，博导
教学情况
主讲本科生课程：《生物化学》
承担的项目与课题
1.主持国家自然科学基金优秀青年科学基金项目：《核酸化学生物学》（2018年）
2. 主持国家自然科学基金委员会重大研究计划培育项目：《可调控CRISPR-Cas系统发展及用于核酸表观遗传修饰动态调控研究》（2019年）
获奖与荣誉
1. 2020年湖北省自然科学一等奖 （3/5）；
2. 2017年获国家自然科学基金委优秀青年科学基金项目；
3. 2016 年获武汉大学优秀教学研究论文二等奖；
4. 2014年入选武汉大学“351人才计划”珞珈青年学者；
5. 2014年获武汉大学化学与分子科学学院青年教师教学竞赛一等奖；
6. 第十二届湖北省挑战杯竞赛特等奖指导教师；
7. 第十六届全国挑战杯竞赛三等奖指导教师 。
代表性成果
1. Wei Xiong#, Xingyu Liu#, Qianqian Qi#, Huimin Ji, Fengbo Liu, Cheng Zhong, Simin Liu, Tian Tian*, and Xiang Zhou. Supramolecular CRISPR-OFF switches with host-guest chemistry. Nucleic Acids Research, 2022, 50, 1241-1255
2. Shaoru Wang#, Lingyu Wu#, Haiyan Huang#, Wei Xiong, Jian Liu, Lai Wei, Ping Yin, Tian Tian*, Xiang Zhou*. Conditional control of RNA-guided nucleic acid cleavage and gene editing. Nature Communications, 2020, 11, 91.
3. Shaoru Wang#, Haiyan Huang#, Jian Liu, Lai Wei, Lingyu Wu, Wei Xiong, Ping Yin, Tian Tian*, Xiang Zhou*. The manipulation of RNA-guided nucleic acid cleavage with ninhydrin chemistry. Advanced Science, 2020, 11, 1903770.
4. Shaoru Wang#, Jiaqi Wang#, Boshi Fu#, Kun Chen, Wei Xiong, Lai Wei, Guangyan Qing, Tian Tian*, Xiang Zhou* Supramolecular coordination-directed reversible regulation of protein activities at epigenetic DNA marks. Journal of the American Chemical Society, 2018, 140, 15842-15849.
5. Shaoru Wang#, Yan-Yan Song#, Lai Wei, Chaoxing Liu, Boshi Fu, Jiaqi Wang, Xiran Yang, Yinong Liu, Simin Liu, Tian Tian* Xiang Zhou*, Cucurbit[7]uril-Driven Host–Guest Chemistry for Reversible Intervention of 5-Formylcytosine-Targeted Biochemical Reactions, Journal of the American Chemical Society, 2017, 139, 16903-16912.
6. Yuqi Chen#, Tingting Hong#, Shaoru Wang , Jing Mo , Tian Tian* and Xiang Zhou* Epigenetic modification of nucleic acids: from basic studies to medical applications, Chemical Society Reviews, 2017, 46, 2844-2872.
7. Shaoru Wang#, Yuanqin Min#, Jiaqi Wang, Chaoxing Liu, Boshi Fu, Fan Wu, Lingyu Wu, Zhixian Qiao, Yanyan Song, Guohua Xu, Zhiguo Wu, Gai Huang, Nanfang Peng, Rong Huang, Wuxiang Mao, Shuang Peng, Yuqi Chen, Ying Zhu, Tian Tian*, Xiaolian Zhang*, Xiang Zhou*, A highly conserved G-rich consensus sequence in hepatitis C virus core gene represents a new anti–hepatitis C target, Science Advances, 2016, 2, e1501535.
8. Shaoru Wang#, Qiuyan Zhang#, Jiaqi Wang#, Xingyi Ge, Yanyan Song, Yafen Wang, Xiaodan Li, Boshi Fu, Guohua Xu, Bo Shu, Peng Gong, Bo Zhang*, Tian Tian*, Xiang Zhou*, Chemical Targeting of a G-Quadruplex RNA in the Ebola Virus L Gene, Cell Chemical Biology, 2016, 23, 1113-1122.
9. Shaoru Wang#, Yuelin Long, Jiaqi Wang, Yushu Ge, Pu Guo, Yi Liu, Tian Tian*, Xiang Zhou*, Systematic investigations of different cytosine modifications on CpG dinucleotide sequences: The effects on the BZ transition, Journal of the American Chemical Society, 2014. 136, 56-59.
10. Shaoru Wang#, Yanyan Song#, Yafen Wang, Xin Li, Boshi Fu, Yinong Liu, Jiaqi Wang, Lai Wei, Tian Tian*, Xiang Zhou*, The m6A methylation perturbs the Hoogsteen pairing-guided incorporation of an oxidized nucleotide. Chemical Science 2017, 8, 6380-6388.
11. Shaoru Wang#, Jiaqi Wang#, Xiaoe Zhang#, Boshi Fu, Yanyan Song, Pei Ma, Kai Gu, Xin Zhou, Xiaolian Zhang, Tian Tian*, Xiang Zhou*, N6-Methyladenine hinders RNA- and DNA-directed DNA synthesis: application in human rRNA methylation analysis of clinical specimens, Chemical Science, 2016, 7, 1440-1446.
12. Shaoru Wang#, Lai Wei#, Jiaqi Wang#, Huimin Ji#, Wei Xiong, Jian Liu, Ping Yin, Tian Tian*, Xiang Zhou*. Light-driven activation of RNA-guided nucleic acid cleavage. ACS Chemical Biology, 2020, 15 (6), 1455–1463.
13. Zhiguo Wu#, Tian Tian#, Junping Yu, Xiaocheng Weng, Yi Liu, Xiang Zhou*, Formation of Sequence㊣ndependent Z〥NA Induced by a Ruthenium Complex at Low Salt Concentrations, Angewandte Chemie International Edition, 2011, 50, 11962-11967.
14. Shaoru Wang#, Boshi Fu, Jiaqi Wang, Yuelin Long, Xiaoe Zhang, Shuang Peng, Pu Guo, Tian Tian*, Xiang Zhou*, Novel Amplex Red Oxidases Based on Noncanonical DNA Structures: Property Studies and Applications in MicroRNA Detection, Analytical Chemistry, 2014, 86, 2925-2930.
15. Shaoru Wang#, Boshi Fu#, Shuang Peng, Xiaoe Zhang, Tian Tian*, Xiang Zhou*, The G-triplex DNA could function as a new variety of DNA peroxidase, Chemical Communications, 2013, 49, 7920-7922.
16. Tian Tian#*, Jiaqi Wang, Xiang Zhou*, A review: microRNA detection methods, Organic & Biomolecular Chemistry, 2015, 13, 2226-2238.
17. Jiaqi Wang#, Shaoru Wang#, Cheng Zhong#, Tian Tian*, Xiang Zhou*, Novel insights into a major DNA oxidative lesion: its effects on Z-DNA stabilization, Organic & Biomolecular Chemistry, 2015, 13, 8996-8999.
18. Zhiguo Wu#, Mingliang Tang, Tian Tian*, Jianguo Wu, Yuanlin Deng, Xiaohu Dong, Zheng Tan, Xiaocheng Weng, Zhihong Liu, Chunjiang Wang, Xiang Zhou*, A specific probe for two-photon fluorescence lysosomal imaging, Talanta, 2011, 87, 216-221.
