教育与工作经历

2000.09-2004.07    武汉大学，化学，学士

2004.09-2010.07    武汉大学，有机化学，博士 ，导师：周翔教授

2008.08-2009.08    法国格勒诺布尔一大，化学，导师：Jean F. Constant

2009.09-2010.06    美国弗吉尼亚大学，有机化学，导师：Lin Pu教授

2010.09-2011.12    Wake Forest University，导师:Lindsay R. Comstock

2012.01-至今         武汉大学化学与分子科学学院， 副教授，博导

教学情况

1.主讲本科生课程：《有机化学》

2.主讲研究生课程：《高等生物有机化学》

3.共同指导本科生获得全国大学生“挑战杯”一等奖

承担项目与课题

1. 国家自然科学基金面上项目(2016)， DNA中甲基、羟甲基、醛基胞嘧啶多位点检测及胞嘧啶羟甲基修饰的方法研究.

2. 国家自然科学基金青年基金(2014)，新型可诱导DNA甲基转移酶和组蛋白甲基转移酶抑制剂的设计合成,构效关系和活性研究。

3. 北京大学天然药物及仿生药物国家重点实验室开放课题(2014)， 20013BLKF249

研究方向

1.小分子探针的开发：开发针对非规则核酸如甲基化核酸、Z型DNA、碱基错配、G四链体结构、交联核酸的小分子探针，能够选择性的作用于这些特殊核酸结构及位点，并且将探针分子与光响应的小分子、药物分子、纳米材料结合，达到生物学研究中的选择性检测或治疗的目的。

2.核酸表观遗传修饰的检测：开发针对DNA甲基化、microRNA、环状RNA的高选择性、高灵敏度的检测方法，并实现了在临床肿瘤样品中的应用。 团队围绕着修饰核酸，包括表观遗传学修饰以及人工修饰的核酸，在核酸的检测、调控方面取得了一些成果，发现了一些比较好的检测方法和调控手段，下一步我们希望在现有基础上利用这些研究方法和手段，能够在基因层面上对相关的生物功能和机理的研究取得一些突破，并真正将检测技术应用于临床疾病的早期检测和诊断。

学术论文

1. Zhang Y.; Yan S.; Chen Z.; Jiang X.; Rao S.; Jiang Z.; Qin S.; Zhou X.; Du Y. D ; Visually Intracellular Detection of Telomerase Activity Based on DNA Strand Displacement Reaction and Gold Nanoparticle Labeling, Chinese Journal of Chemistry, 2022, 40: 693-698

2. Yajun Zhang; Qiuyang Zhang; Xiaocheng Weng; Yuhao Du Y ; Xiang Zhou ; NEase-based amplificat ion for detection of miRNA, multiple miRNAs and circRNA, Analytica Chimica Acta, 2021, 1145: 52-5 8

3. Yaqian Liu, Xiong Zhang, Min Liu, Fa Xu, Qiuyang Zhang, Yajun Zhang, Xiaocheng Weng, Songmei Liu, Yuhao Du*, Xiang Zhou, Direct detection of circRNA in real samples using reverse transcription-rolling circle amplification, Anal. Chim. Acta., 2020, 1101: 169-175,

4. Min Liu, Wu Fan, Yuhao Du*, Xiang Zhou*, Specific stabilization of DNA G-quadruplex structures with a chemically modified complementary probe，Bioorg. Med. Chem. 2019, 27, 1962

5. Yinong Liu, Cheng Zhong, Zhiyong He, Shuang Rao, Haomiao Su, Fan Wu, Boshi Fu, Jinjun Wu, Yanyan Song, Yuhao Du*, and Xiang Zhou* . Sensors and Actuators B, 2018, 255, 2151

6. Zhiyong He, Chen, Yuqi Chen, Yafen Wang, Jiaqi Wang, Jing Mo, Boshi Fu, Zijing Wang, Xiang Zhou*, Yuhao Du*, A rapidly photo-activatable light-up fluorescent nucleoside and its application in DNA base variation sensing, Chem. Commun, 2016, 52, 8545.

7. Shuang Rao, Yuqi Chen, Tingting Hong, Zhiyong He, Shan Guo, Han Lai, Ge Guo, Yuhao Du*，Xiang Zhou*，Simultaneous and Sensitive Detection of Multisite 5-Methylcytosine Including Non-CpG Sites at Single-5mC-Resolution. Anal. Chem, 2016, 88, 10547.

8. Yuhao Du*, Xiang Zhou*, Targeting non-B-form DNA in living cells. Chem. Rec, 2013, 371.

9. Yuhao Du, Charles Hendrick, Krysta Frye, Lindsay Comstock*, Fluorescent DNA labeling by N-mustard analogues of S-adenosyl-L-methionine. ChemBioChem, 2012, 13, 2225.

10. Mark Turlington, Yuhao Du, Samuel G Ostrum, Wren Vishaka, Tony Lin, Michal Sabat，Lin Pu*, From highly enantioselective catalytic reaction of 1,3-diynes with aldehydes to facile asymmetric synthesis of polycyclic compounds. J. Am. Chem. Soc., 2011, 133, 11780。

11. Yuhao Du, , Xiaocheng Weng, Jing Huang, Dan Zhang, Heng Ma, Dong Chen, Xiang Zhou*, Constant, Jean-Francois, Oligonucleotide-selenide conjugate: synthesis and its inducible sequence-specific alkylation of DNA. Bioorg. Med. Chem. 2010, 18, 4149.

12. Yuhao Du, Mark Turlington, Xiang Zhou, Lin Pu*, Highly enantioselective addition of linear alkyl alkynes to linear aldehydes. Tetrahedron Lett., 2010, 51, 5024. (IF: 2.259, 三区)

13. Yuhao Du, Dan Zhang, Wei Chen, Ming Zhang, Yangyang Zhou, Xiang Zhou*, Cationic N-confused porphyrin derivative as a better molecule scaffold for G-quadruplex recognition. Bioorg. Med. Chem. 2010, 18, 1111.

14. Yuhao Du, Jing Huang, Xiaocheng Weng, Xiang Zhou*, Specific Recognition of DNA by Small Molecules. Curr. Med. Chem. 2010, 17, 173.